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Electroporation

TonaPulse® – A Flexible Electroporation System

Next-generation lab high-voltage pulse generator

TonaPulse® is a lab system designed for generating monophasic and biphasic high-voltage pulses with exceptional flexibility and precision. Its unique vertical design and fan-less construction allows convenient placement directly inside laminar flow cabinets, minimizing the risk of cell contamination during experiments.

The system features a 7” touchscreen display with an intuitive user interface and supports the storage of up to 500 experimental sequences in its internal memory. Pulses can be generated in the range of 50 V – 1500 V and with durations from 250 ns to 100 ms. The device supports symmetrical and asymmetrical pulses—both in voltage and timing—and enables reversible as well as irreversible electroporation.

Key Parameters

Monophasic and biphasic pulses with fully customizable sequences

Voltage range: 100 V – 1.5 kV

Pulse duration: 250 ns – 100 ms

Supports both reversible and irreversible electroporation

Wide range of applications: from cell cultures to clinical research

TonaWell – Fully Sterilizable System for Adherent Cell Cultures

Next-generation lab high-voltage pulse generator

TonaPulse® is offered with the fully sterilizable TonaWell® accessory, designed specifically for adherent cell cultures. TonaWell ensures highly homogeneous electric fields and minimal thermal effects, while the automated TonaMatrix switching system significantly accelerates experiments and reduces costs by up to 80% compared to conventional solutions.

TonaWell96 – Key Features

Fully resterilizable in a standard autoclave
Highly homogeneous electric fields across all wells
Minimized thermal effects
Automated workflow with the integrated switching matrix
Significantly accelerates laboratory workflows and reduces costs
Universal solution (compatible with any electroporation generator)

Optional Accessories

TonaMatrix switching matrix for automated execution of up to 32 experiments in a single cycle
Precision electrodes for accurate application of electric fields
Active high-voltage probes for multichannel in situ measurements using an oscilloscope
Specialized media for in vitro electroporation

Application Areas

Oncology – enhancing pharmacotherapy effectiveness through electrochemotherapy

Genetic Engineering – plasmid delivery, CRISPR cell modification

Cardiology – application of electrical pulses in the treatment of cardiac arrhythmias

Research Laboratories – cell culture experiments, preclinical research

Science and TonaPulse®

10.10.2025

Тonagena at NYC Tech Week and ESGCT 2025: International Debut of the TonaPulse® System

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